Sage has been used effectively for throat infections, dental abscesses, infected gums and mouth ulcers. The phenolic acids in Sage are particularly potent against Staphylococcus aureus. In vitro, sage oil has been shown to be effective against both Escherichia coli and Salmonella species, and against filamentous fungi and yeasts such as Candida albicans. Sage also has an astringent action due to its relatively high tannin content and can be used in the treatment of infantile diarrhoea.

Its antiseptic action is of value where there is intestinal infection. Rosmarinic acid contributes to the herb's anti-inflammatory activity.

Sage has an anti-spasmodic action which reduces tension in smooth muscle, and it can be used in a steam inhalation for asthma attacks. It is an excellent remedy for helping to remove mucous congestion in the airways and for checking or preventing secondary infection.